Despite in spanish

A pesar de

pronunciation: ɑpesɑɹ̩de part of speech: noun
In gestures

despite = a pesar de (que), pese a, con independencia de, al margen de. 

Example: The scheme covers all knowledge, despite being special in purpose.

more:

» despite everything = a pesar de todo.

Example: The novel describes people waging an unequal struggle against circumstances and remaining hopeful despite everything.

» despite it all = a pesar de todo.

Example: However, despite it all, Ludlam remains something of an enigma.

» despite the fact that = a pesar de (que), pese a, con independencia de, al margen de.

Example: Strangely enough, despite the fact that he was buddies with Henry Kissinger at Harvard, he is registered as a member of the Democratic Party.
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